Inferring the cellular and molecular complexity of health and disease from liquid biopsies using advanced computational modelling

Posted by Erasmus MC/TU Delft 285 days ago

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on the topic of lidquid biopsies, supported by the Convergence initiative. Liquid biopsies contain various tumour-derived materials, including circulating tumour cells, tumour-educated platelets, extracellular vesicles, as well as circulating tumour DNA/RNA (ctDNA/ctRNA) which all can currently be interrogated by various types of next generation sequencing approaches each providing a partly complementary view on the disease in situ.  Clinical and translational scientists from the Departments of Medical oncology, Urology and Surgery from the Erasmus University Medical Center Rotterdam (Erasmus MC) and computational scientists from Delft University of Technology (TU Delft) join forces in this project. As a postdoctoral researcher you will develop and implement advanced computational methods to infer disease state from multi-omics data from serial liquid biopsies taken from cancer patients at critical time points during their disease to allow for superior treatment decisions. These methodologies will be studied within three common cancer types: prostate cancer (urine-based assays), colorectal and breast cancer (blood-based read-outs).

Qualifications for both post docs:

  • A strong methodological background and preferably a PhD degree in Bioinformatics, Computer Science, Computational Cancer Biology or a related field.
  • Knowledge of Machine Learning, (Bio)statistics, Data Integration, Data Normalization, building predictors and workflows will be considered a plus.

Expectations 

The postdocs should have a deep interest in the convergence of health sciences, physical sciences, and engineering to foster individual health and keep the healthcare system sustainable. They will work closely with the supervisors, Principal investigators and Collaborating investigators of the project to conduct high calibre research. They are also encouraged to initiate and lead collaborative work with other postdocs within the Convergence for health(care) initiative. Salary will be commensurate with qualification and experience.

About this position

Recruitment takes place until the vacancy is filled.
Hours a week: 36

Contact information:

Prof. Ir. Guido Jenster
Erasmus MC
g.jenster@erasmusmc.nl
Prof. Ir. Marcel Reinders
TU-Delft
m.j.t.reinders@tudelft.nl

Interested?

Inferring the cellular and molecular complexity of health and disease from liquid biopsies using advanced computational modelling